Global Gastrointestinal Drug Market To Grow $48.4 Billion By 2022

1Summary
Disease and disorders involving the gastrointestinal system are among the most common conditions encountered worldwide, and many of them can have a significant impact on quality of life. The direct and indirect socio-economic burden associated with gastrointestinal disorders is profound. The direct costs of medical consultations and treatments in the US for gastroesophageal reflux disease alone are estimated to amount to $9.3 billion, while the indirect costs due to absenteeism and impairment in work performance total $75 billion (Chait, 2010).

Despite the significant global socio-economic burden, many gastrointestinal disorders are still poorly understood, and there is a significant unmet need for novel, safe and effective therapies, as treatment options are often lacking, causing many patients to be dissatisfied with their treatment. The unmet need and demand for better treatments and the high prevalence of digestive conditions make the gastrointestinal market an attractive candidate for therapeutic development.

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This report covers all gastrointestinal disorders, but there is a particular focus on three key diseases: gastroesophageal reflux disease, irritable bowel syndrome and inflammatory bowel disease. The global gastrointestinal market was valued at $35.7 billion in 2015 and is projected to grow at a compound annual growth rate (CAGR) of 4.45%, reaching $48.4 billion in 2022. Proton pump inhibitors (PPIs) and tumor necrosis factor (TNF)-? inhibitors generate the largest revenues and continue to retain commercial prominence. Key drivers of market growth will be the uptake of recently approved premium products, rising prevalence, and promising late-stage products, including a number of biologic therapies that are expected to be highly valuable.

Scope

The gastrointestinal market landscape is expected to change substantially with the advent of promising novel pipeline products.

There are 937 gastrointestinal pipeline products in active development, of which small molecules and biologics account for 53% and 38%, respectively.

  • Which molecular targets are most prominent within the pipeline?
  • How do the key indications differ in terms of molecule type?
  • How does the composition of the pipeline compare with that of the existing market?
  • What mechanisms of action are most common for pipeline drugs?
  • Global revenue for the gastrointestinal market is forecast to grow at a CAGR of 4.45%, from $35.7 billion in 2015 to $48.4 billion in 2022.
  • Which products will be the biggest drivers for market growth?
  • Will the current market leaders retain their dominance over the forecast period, and how is their revenue share of the gastrointestinal market set to change?
  • What CAGR will these companies register in the forecast period?

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Reasons To Buy

This report will allow you to –

  1. Understand the current clinical and commercial landscape by considering disease pathogenesis, diagnosis, prognosis and the treatment options available at each stage of diagnosis.
  2. Visualize the composition of the gastrointestinal market across each indication, in terms of dominant molecule types and targets, highlighting the key commercial assets and players.
  3. Analyze the gastrointestinal pipeline, stratifying it by stage of development, molecule type and molecular target and providing a granular breakdown across key indications.
  4. Understand the growth in patient epidemiology and market revenue for the gastrointestinal market globally and across the key players and product types.
  5. Stratify the market in terms of the split between generic and premium products and assess the role of these product types in the treatment of the various gastrointestinal conditions.
  6. Identify commercial opportunities in the gastrointestinal deals landscape by analyzing trends in licensing and co-development deals.

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Global Cancer Vaccines Market To Reach $7.5 Billion By 2022

1Summary
Cancer vaccines are being developed as a method of preventing certain types of cancer, and as therapeutic treatments to treat existing cancers across a range of indications in oncology, either as stand-alone therapies or in combination with traditional cancer therapeutics such as chemotherapy and surgery. The high mortality rate associated with cancer and its resistance to conventional treatments such as radiation and chemotherapy has led to the investigation of a variety of anti-cancer immunotherapies, which have a lower toxicity associated with their use than traditional chemotherapies.

Therapeutic vaccine administration will increase the overall survival of poor-performance-status patients, and enable more rounds of treatment to be given – factors that will contribute to growing global revenues for this class of therapy. However, cancer vaccines are not perceived as having strong commercial potential, as immune checkpoint inhibitors are expected to dominate the treatment landscape for leukemia and lymphoma during the forecast period.

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A number of common etiologic factors have been strongly characterized as raising the risk of developing cancer, including age, chronic inflammation, gender, obesity, tobacco usage and heritable cancer syndromes. The risk of cancer increases greatly in patients over the age of 65. Populations in developed countries are projected to become increasingly aged and show rising obesity incidence, which will drive cancer prevalence and revenue growth for its treatments.

Prophylactic vaccines are currently used to immunize against viruses, which have been shown to increase the risk of cancer, with viral factors being the underlying cause of approximately 15% of cancers worldwide. Prophylactic vaccines such as Gardasil are currently the most commercially successful and well-established class of cancer vaccines. However, there has been a shift towards the clinical testing of therapeutic vaccines – which constitute the majority of the pipeline – such as Imlygic, which was recently approved for melanoma.

Scope

  • Global revenues for the cancer vaccines market are forecast to grow at a compound annual growth rate (CAGR) of 16.93%, from $2.5 billion in 2015 to $7.5 billion in 2022.
  • Which drugs will achieve blockbuster status and how will the key player companies perform during the forecast period?
  • The cancer vaccine pipeline is large and fairly diverse, and contains 1,286 products.
  • How does the composition of the pipeline compare with that of the existing market?
  • What are the most popular molecule types and molecular targets in the pipeline?
  • What mechanisms of action and molecule types are most common for pipeline vaccines being trialed in the various key indications?
  • How will the market shares and CAGRs of the top 20 pharma companies compare within cancer vaccines?
  • What proportion of the key players’ revenues will be attributable to cancer vaccines?

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Reasons To Buy

This report will allow you to –

  1. Understand the current clinical and commercial landscape by considering disease pathogenesis, diagnosis, prognosis, and the treatment options available at each stage of diagnosis
  2. Visualize the composition of the cancer vaccines market across each indication, in terms of dominant molecule types and targets, highlighting the key commercial assets and players
  3. Analyze the cancer vaccine pipeline and stratify by stage of development, molecule type and molecular target, with a granular breakdown across key indications
  4. Understand the growth in patient epidemiology and market revenues for the cancer vaccine market globally and across the key players and product types
  5. Stratify the market in terms of the split between therapeutic and prophylactic vaccines, and assess the role of these product types in the treatment of the various cancers
  6. Identify commercial opportunities in the cancer vaccine deals landscape by analyzing trends in licensing and co-development deals

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Global Cancer Immunotherapies Market To Rise $75.8 Billion By 2022

1Summary
Cancer is a group of diseases characterized by abnormal cell growth. It is a multi-step process, as a single mutation is almost certainly insufficient to cause a cell to become malignant. A number of cellular processes must be deregulated to allow cells to proliferate uncontrollably while evading apoptosis. Initially, key cell growth, proliferative and pro-apoptotic signaling pathways are deregulated in most cancers. These signaling pathways enable cell survival, continued proliferation, and the avoidance of programmed cell death.

It is now widely believed that many tumors express antigens that can be identified by the adaptive immune system, and that can therefore potentially be used to produce an anti-tumor immune response. The immune system is believed to have the greatest potential in terms of treating cancer, as there is evidence tumors are recognized by the immune system, and this tumor-specific immune response is due to the recognition of tumor antigens. However, in many cancers, disease progression is also accompanied by immune suppression, which hinders an effective anti-tumor response and tumor elimination.

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Over the past few decades cancer immunotherapies have developed into important therapeutic options for some types of cancer. Some of these therapies generally enhance the activity of the body’s immune system, while others drive the immune system to target specific cancer cells.

The different types of cancer immunotherapies used to treat cancer include monoclonal antibodies (mAbs) directed at specific tumor-associated antigens (TAA); immune checkpoint inhibitors, which target key proteins involved in the immune response, such as programmed cell death-1 (PD-1); cancer vaccines, which can be used to stimulate an immune response in a patient; and non-specific immunotherapies, which are therapies that do not target cancer cells specifically, but stimulate the immune system in a more general way, such as interferon therapy.

Overall, there are 2,037 products in active development in the cancer immunotherapy pipeline. This makes it a notable portion of the entire oncology pipeline, and reflects the strong interest in this class of therapy in product development. This is due to growing clinical rationale behind developing such therapies, and the willingness of drug developers to invest in novel therapeutics, which will offer significant product differentiation from market competitors.

The leading indications in terms of cancer immunotherapy product development are breast cancer, melanoma, non-small-cell lung cancer (NSCLC) and ovarian cancer, which are the focus of this report. This is based on the high level of activity in terms of cancer immunotherapy product development in these specific oncology indications, with the aforementioned indications ranking highest in this regard.

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Scope
The cancer immunotherapies market already consists of some commercially successful products.

  • Which classes of drug dominate the market?
  • What additional benefits have newly approved therapies brought to the market?
    The cancer immunotherapies pipeline is vast, with a significant degree of diversity in terms of molecule types and targets.
  • Which molecular targets appear most frequently in the pipeline?
  • What are the commercial prospects for the most promising late-stage pipeline products?
  • The cancer immunotherapies market is forecast to rise from a value of $16.9 billion in 2015 to $75.8 billion in 2022, at a compound annual growth rate of 23.9%.
  • Which products are forecast to drive this substantial degree of growth?
  • Will generic competition have a significant impact on the market over the forecast period?
  • The company landscape is growing increasingly competitive.
  • What are the leading companies in terms of market share?
  • Which companies are forecast to experience the greatest growth in market share?
  • What are the drivers of growth for key companies in the market?
  • How dependent are the key companies on this disease cluster for revenue?
  • Which companies rely heavily on this disease cluster for revenue?

Reasons To Buy
This report will allow you to –

  1. Understand the current clinical and commercial landscape through a comprehensive study of disease epidemiology, pathogenesis, symptoms, diagnosis and prognosis for the key indications covered in the report, which includes breast cancer, melanoma, NSCLC and ovarian cancer.
  2. Assess the current treatment landscape, with product profiles covering prominent marketed therapies, including revenue forecasts.
  3. Analyze the cancer immunotherapies pipeline and stratify by stage of development, molecule type, and molecular target. The most promising late-stage therapies are profiled and assessed in terms of clinical performance and competitiveness, alongside a single-product forecast.
  4. Predict growth in market size, with in-depth market forecasting from 2015 to 2022. The forecasts will provide an understanding of how epidemiology trends, new drug entries, and patent expirations will influence market value.
  5. Identify the leading companies in the market, in terms of market share and growth. Company analysis determines how dependent the key companies in the market are on revenue derived from cancer immunotherapy products. In addition, analysis determines the primary factors that will drive market growth for the key companies in the market.
  6. Identify commercial opportunities in the cancer immunotherapies deals landscape by analyzing trends in licensing and co-development deals.

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Diabetes & Obesity Drug Development Market To Grow At A Lucrative Rate, 2016

1Summary

The diabetes and obesity disease cluster is currently dominated by therapeutics indicated for type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), and the majority of the pipeline, in terms of both quantity and quality of products, is attributable to these indications. While products indicated for obesity do not currently have a large market presence, there are a large number of these products in the pipeline, with the majority in early stages of development.

The combined therapy area of diabetes and obesity presents a strong pipeline, accounting for a large proportion of the overall metabolic disorders therapy area. The majority of products are small molecules and biologics, which reflects the overall pharmacotherapeutic market trend.

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An increasing pipeline presence for obesity-indicated products and overwhelming global media interest highlight the relevance of this indication and its future potential global revenues. However, the number of pharmacotherapeutic products for obesity is dwarfed by diabetes-indicated products. Given the status of obesity as a risk factor for T2DM, it is likely that the T2DM pipeline will continue to grow with the rising obesity incidence.

Scope

  • Which companies are the most active within the pipeline for diabetes and obesity?
  • Which pharmaceutical approaches are the most prominent at each stage of the pipeline and within each indication?
  • To what extent do universities and institutions play a role within this pipeline, compared with pharmaceutical companies?
  • What are the most important R&D milestones and data publications to have occurred in this disease area?

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Reasons To Buy

  1. Understand the overall pipeline, with an at-a-glance overview of all products in therapeutic development for each indication.
  2. Assess the products in development in granular detail, with an up-to-date overview of each individual pipeline program in each indication, and a comprehensive picture of recent updates and milestones for each.
  3. Analyze the companies, institutions and universities currently operating in the pipeline, and the products being fielded by each of these.
  4. Understand the composition of the pipeline in terms of molecule type, molecular target, mechanism of action and route of administration.

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Global Fire Trucks Market Is Projected To Reach USD 7.41 Billion By 2024

1Growing demand for fire trucks owing to rising penetration in application segments, including residential & commercial, enterprises & airports, and military, is expected to drive market growth over the forecast period.

Growing infrastructure in the developing countries including India, China, South Korea coupled with increasing awareness regarding fire safety is expected to drive the demand for fire trucks over the next eight years. The demand in enterprises and airports for fire apparatus and increasing governmental regulations towards ensuring fire safety compliance is expected to be a contributing factor for market growth across the globe.

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The market consists of raw material suppliers, manufacturers, distribution channels, and end user applications. The companies including Alexis Fire Equipment Co. and Xuzhou Handler Special Vehicle Co. Ltd. procure raw materials such as chassis and metal sheets required for manufacturing of fire trucks from the local suppliers, as it saves transportation costs. However, few companies including Gimaex International and Albert Ziegler GmbH purchase trucks instead of chassis from established truck manufacturers such as MAN and Scania, install the components and fire equipment, and sell them to the fire departments.

Further key findings from the report suggest:

Residential & commercial application accounted for over 40% of the overall fire trucks market. Growing global population and resultant surge in building & construction activities have led the government to enforce stringent fire safety regulations across all sectors. This resulted in a significant increase in demand for fire trucks and is expected to drive market growth significantly over the forecast period.

China demand for fire truck was valued at over USD 650 million in 2015. High production capacity coupled with inexpensive labor are expected to be the driving forces for rising demand and supply for fire trucks in the country.In addition, growing application in manufacturing sector and residential sector is expected to aid market growth in China.

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North America accounted for a large share of the market, and is expected to witness significant growth, growing at over 6% over the forecast period. Large number of fire stations and stringent regulations regarding fire safety are expected to be the key factors for market growth in the region.

The market in Europe, Middle East & Africa (EMEA) is expected to grow at a CAGR of over 5%. Product innovation, coupled with technological advancements in the industry, is expected to be the drivers of the EMEA market. However, high import prices are expected to restrain fire trucks market growth in Middle East & Africa.

Key players in the industry include Rosenbauer International AG, Oshkosh Corporation and Magirus GmbH. Auxiliary Power Unit is an idle-reduction technology designed by Rosenbauer International AG, specifically for use on fire apparatus; this is expected to save operating costs of endusers by a huge margin.

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Global Butane Market Size Is Predicted To Reach USD 81.62 Billion By 2025

1Increasing monetary assistance from respective governments in the form of subsidies for LPG coupled with expanding population is expected to drive the market over the forecast period. Growing population and disposable income is projected to push the market growth over the coming years.

Rising industrialization coupled with capacity expansions of refineries in emerging economies of China and India is expected to fuel the butane industry demand. Growing concern regarding the impact of conventional fuel on the environment is projected to boost the LPG application market.

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Increasing need for energy supply in automotive sectors is anticipated to drive the growth for butane industry. Wide range of applications of butane in petrochemicals, refrigerants, as a fuel for cigarette lighters, as propellants in aerosol sprays is expected to augment the market positively.

Growing demand for energy consumption on account of rapid urbanization is anticipated to augment butane market over the coming years. Companies such as Valero Energy Corporation, Energy Corporation of America, and Praxair adopted expansion strategies to enhance the production capacity.

Further Key Findings from the Study Suggest:

LPG segment dominated the butane application in 2015 accounting for over 66.6% of the global market

Increased demand for LPG in residential, commercial, industrial, and refinery is expected to boost the LPG market

Butane gas is used in LPG application areas including residential, industrial, autofuel, refinery, and petrochemicals among others

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Residential & commercial segment is expected to be inhigh demand for LPG application industry by 2025 accounting for over 50.2% of the overall market

Asia Pacific region is anticipated to grow at a significant rate of 4.2% over the forecast period owning to growing demand for fuel gas

U.S. EPA has filed litigation on the use of MTBE for gasoline blending owing to increased incidences of groundwater contamination

Rising investment on LNG by the governments is leading to the production of butane gas, in addition to R&D is expected to propel the market over the coming years

Companies such as Sinopec Group, Valero Energy Corporation, and Total S.A. offerservices for refining, industrial, and nuclear power sectors among othersis projected to propel growth of the market

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Global BIPV Market Size Is Forecasted To Reach USD 31.14 Billion By 2024

1Rising adoption of energy generation by renewable sources without comprising on the aesthetic appeal of buildings is expected to drive growth over the forecast period.

Increasing demand for integrated installations is expected to be driven by the growing disposable income of the consumers. In addition, rising concerns regarding averse environmental impact due to the use of non-renewable energy sources are likely to account for the growth of the industry over the next eight years.

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The industry has witnessed increased adoption of the environment-friendly energy sources by the multi-national corporations to limit the carbon footprints. In addition, growing subsidies and tax reductions offered by the national governments is expected to bolster the demand for the product.

The demand for the product has stemmed from the increased adoption of the integrated roofs, walls and windows owing to superior aesthetic properties. In addition, the industry has witnessed increased efforts towards the research & development activities leading to the development of magnetic nanoparticles incorporated solar cells, leading to an enhanced efficiency of the overall installation.

Further key findings from the report suggest

Building integrated roofs accounted for over 61% of the overall revenue due to superior efficiency of the roof-integrated systems. In addition, improved aesthetic appeal coupled with the ease of the integration of the solar energy harnessing systems for rooftop installations.

Thin-film building integrated photovoltaics is expected to witness highest CAGR of over 20% from 2016 to 2024 due to superior integration with the building envelopes in comparison to the crystalline silicon.

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The thin film is expected to grow owing to significant technology advancements leading to improved performance efficiency as well as superior aesthetic appeal as compared to its counterparts.

The market in Asia Pacific is expected to account for USD 7.48 Billion by 2024 due to increasing demand for the technology from the rapidly developing building and construction industry in the region.

The companies in the market are involved in significant research & development activities to produce advanced products, in a bid to increase the market share. Heliatek GmbH introduced the organic building integrated photovoltaic cells, with high band gap resulting in superior efficiency.

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Global Automotive LiDAR Market Is Expected To Reach USD 223.2 Million By 2024

1The surging acceptance of automobile safety application arenas and sophisticated technology incorporations in automobile driving automation are expected to boost the market growth. The increasing acceptance for semi-autonomous and autonomous cars in the years to come is further anticipated to bolster the market growth.

The market can be categorized, based on application types, into Advanced Driver Assistance Systems (ADAS) & autonomous cars. The ADAS application segment is further segregated into Automatic Emergency Braking (AEB) and Adaptive Cruise Control (ACC).

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The ADAS application segment is expected witness a significant growth, owing to the surging incorporation of forward-collision avoidance systems.Adaptive cruise control (ACC) is adiscretionary cruising choice for automobiles that robotically modifies the vehicle speed to retain a safe distance from vehicles ahead.The rising adoption of these systems in autonomous and semi-autonomous cars at various levels of automation is expected to draw huge ventures from the key participants, thus driving the regional market demand in the years to come.

In October 2016, Infineon Technologies AG (Germany) acquired Innoluce BV (The Netherlands), a fabless semiconductor company headquartered in Nijmegen. Infineon says it would develop chip components for high-performance LiDAR systems by utilizing Innoluce’s patented technology. This acquisition is expected to establish Infineon’s strong foothold as one of the automotive safety technologies vendors.

Further key findings from the report suggest:

The global automotive LiDAR market is estimated to grow significantly over the forecast period due to the automation in the car safety technology, leading to reduced human efforts and increased efficiency

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Extensive R&D by market players,updated ratings of safety agencies and the increasing awareness, among consumers, have fueled the market growth assome major automakers have already started to integrate basic AEB systems as optional and standard options into their mass-market models

The markets in the North American region including the U.S. & Canada and the European regions occupied a marginal proportion of the market share in 2015 on account of the administrative regulations mandating the installation of certain automotive safety technologies in both light weight and heavy weight vehicles in the region

The key industry participants include Robert Bosch GmbH, Denso Corporation, Velodyne LiDAR, Inc., Novariant, Inc., LeddarTech, Continental AG, and Quanergy Systems, Inc.

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Global Air Core Drilling Market Value Is Anticipated To Exceed USD 1.45 Billion By 2025: Hexa Reports

1Rising investment in E&P activities across various unconventional energy sources to meet growing energy demand is expected to drive the market over the next nine years.

Air core drilling is widely used in soft rock and soil formations that do not need heavy machinery to drill to the desired depth. The samples produced are not damaged and can be easily analyzed which makes this method better thanrotary air blast drilling.The techniqueis primarily used by mining companies which are looking for minerals that are well below the surface as it can reach depths up to 300 meters.

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Additional benefits of this method include instant switch between complimentary drill bits, continuous sample returns, and reduced times in moving between boreholes which maintain the ore grade of the mineral samples.

Air core drilling takes longer time than other conventional techniques as the process is more accurate.In addition,the technique functions at water devoid, mature geographical areas and hydrogen sulfide zones which is anticipated to limit its usability.

Further key findings from the report suggest:

The “Global Air Core Drilling” demand exceeded USD 900 million in 2015 and is estimated to grow at a CAGR of 5.0% from 2016 to 2025

Nitrogen membrane drillingis anticipated to grow at the highest CAGR of 5.7% from 2016 to 2025 owing to the ability to reduce chances of down hole fires and operating costs.

Dust drilling demand in the U.S. is estimated to exceed USD56.3 million by 2025. High demand for this technique may be attributed to a large number of mature sedimentary basins in the country.

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The Asia Pacific air core drilling industry is expected to grow at the highest CAGR of 5.9% from 2016 to 2024 owing to alarge number of upcoming E&P projects and the presence of huge untapped hydrocarbon reserves.

Key players include Schlumberger, Atlas Copco, Baker Hughes, Weatherford, Allis Chalmers and Halliburton

Harlsan is one of the primary suppliers of RC drill rods and air core bits to major mining players present in Asia, Africa,Canada,UK, and South America. Airdrill manufactures drilling and auxiliary equipment for oil&gas and mining industries

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Global Smart Healthcare Market To Grow At A CAGR of 24.55% By 2020: Hexa Reports

1About Smart Healthcare
Smart healthcare is the integration of different healthcare delivery mechanisms. It makes use of electronic patient records and streamlining processes, which leads to improved quality of life by reducing the risks to health (by remote monitoring and checks) and improving the general well-being of people. Smart healthcare provides more patient-centric services that improves access to healthcare and are customized to individual patients’ needs.

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Covered in this report
The report covers the present scenario and the growth prospects of the global smart healthcare market for 2016-2020. To calculate the market size, the report considers the revenue generated from solutions EHR, telemedicine, mHealth, smart pills, and other (RFID smart cabinets, RFID kanban system, and smart syringe). Revenue generated from customers using services in homes, mobile health, clinics, research/medical centers, hospitals, and care centers.

And from services such as home monitoring, clinical remote monitoring, clinical monitoring, asset management applications, assisting people with disabilities, and the connected medical environment. Revenue generated from services such as digital signage, wireless tags, critical network access, e-medical records, chronic disease management devices, point-of-sale devices, bedside terminals, asset management devices, location monitoring devices, and smartphones and mobile devices.

The market is divided into the following segments based on geography:
• APAC
• Europe
• North America
• ROW

Global Smart Healthcare Market 2016-2020, has been prepared based on an in-depth market analysis with inputs from industry experts. The report covers the market landscape and its growth prospects over the coming years. The report also includes a discussion of the key vendors operating in this market.

Key vendors
• Allscripts
• Cisco
• GE Healthcare
• Philips

Market driver
• Increased demand for remote monitoring of health conditions of aging population
• For a full, detailed list, view our report

Market challenge
• Fragmentation and complexity in market
• For a full, detailed list, view our report

Market trend
• Involvement of big data analytics in healthcare
• For a full, detailed list, view our report

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Key questions answered in this report
1. What will the market size be in 2020 and what will the growth rate be?
2. What are the key market trends?
3. What is driving this market?
4. What are the challenges to market growth?
5. Who are the key vendors in this market space?
6. What are the market opportunities and threats faced by the key vendors?
7. What are the strengths and weaknesses of the key vendors?

You can request one free hour of our analyst’s time when you purchase this market report. Details are provided within the report.